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Coordination of Cell Division with Replication of the Chromosome

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It is not sufficient to know how chromosomes replicate and then segregate into the daughter cells prior to division. Something must coordinate the replication of the chromosome with division of the cells. If the cells divided before the replication of the chromosome was completed, there would not be two complete chromosomes to segregate into the daughter cells, and one cell would end up without a complete chromosome. The mechanism by which cell division is coordinated with replication of the DNA is still not completely understood, but there is a lot of relevant information.

Snyder and Champness Molecular Genetics of Bacteria

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