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1 The Bacterial Chromosome: DNA Structure, Replication, and Segregation

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DNA Structure The Deoxyribonucleotides The DNA Chain The 5′ and 3′ Ends Base Pairing Antiparallel Construction The Major and Minor Grooves

The Mechanism of DNA Replication Deoxyribonucleotide Precursor Synthesis Replication of the Bacterial Chromosome Replication of Double-Stranded DNA

Replication Errors Editing RNA Primers and Editing

Impediments to DNA Replication Damaged DNA and DNA Polymerase III Mechanisms To Deal with Impediments on Template DNA Strands Physical Blocks to Replication Forks

Replication of the Bacterial Chromosome and Cell Division Structure of Bacterial Chromosomes Replication of the Bacterial Chromosome Initiation of Chromosome Replication RNA Priming of Initiation Termination of Chromosome Replication Chromosome Segregation Coordination of Cell Division with Replication of the Chromosome Timing of Initiation of Replication

The Bacterial Nucleoid Supercoiling in the Nucleoid Topoisomerases

The Bacterial Genome

BOX 1.1 Structural Features of Bacterial Genomes

BOX 1.2 Antibiotics That Affect Replication and DNA Structure


Model of the action of the PriA protein restarting a collapsed DNA replication fork. The DNA strands yet to be replicated (parental duplex) and the leading and lagging strands that have been replicated are labeled. The DNA strands shown in cyan and purple indicate regions that are believed to be bound by the PriA proteins based on biochemical experiments. The various subdomains of the PriA proteins are indicated in other colors. From Windgassen et al. (see Suggested Reading).

Snyder and Champness Molecular Genetics of Bacteria

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