Читать книгу Clinical Obesity in Adults and Children - Группа авторов - Страница 78

Since the early 1900s, a number of obese inbred strains of mice, both dominant (yellow, Ay/a) and recessive (ob/ob, db/db, fa/fa, tub/tub), have been studied. In the 1990s, the genes responsible for these syndromes were identified mostly by positional cloning techniques and these observations have given substantial insights into the physiologic disturbances that can lead to obesity, the metabolic and endocrine abnormalities associated with the obese phenotype, and the more detailed anatomic and neurochemical pathways that regulate energy intake and energy expenditure [23]. These studies provide the basic framework upon which the understanding of the more complex mechanisms in humans can be built.