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SLE

•10 times more in females

•More in blacks

•20-30 years of age

•Photosensitivity

•Butterfly facial rash

•Triggered by Procainamide

•ANA

•Anti-ds DNA

•Sm antigen

•Libman-Sachs endocarditis

•Diffuse Glomerulonephritis

Sjogren’s Syndrome

•Middle age women

•HLA-DR3

•Parotid enlargement

•Xerostomia

•Rheumatoid arteritis

•Keratoconjunctivitis

Scleroderma

•AKA. Systemic sclerosis

•Raynaud’s phenomena

•Esophageal fibrosis

•ANA (antinuclear antibody)

•Hyper-gammaglobinemia

•Anticentromere angiopathy

•Xerostomia

Amyloid

•Congo red stain

•Multiple myeloma

•Alzheimer

•Dilated: Congestive

Graves Disease

•Middle-aged female

•Exophthalmia

•Heat intolerance

Hashimato Thyroiditis

•Auto microsomal antibody

•Enlarged thyroid

•Lymphocytic infiltration

•Cold intolerance

•Associated with: SLE, Sjogren’s, chronic hepatitis, HLA-DR5 and DR3

Myasthenia Gravis

See musculoskeletal

Lambert- Eaton Syndrome

•Similar to myasthenia

•Auto-antibody to Ca⁺⁺ channels

•Decreased presynaptic Ach release

•Proximal weakness

Good Pasture’s

•Males

•Autoantibody against basement membrane

•Kidneys and lungs

Dermatomyositis

•Eye and knuckle’s rash

•Bilateral proximal muscle weakness

•Polymyositis

•Increased CPK, SGOT, LDH, and CK

•Subcutaneous calcification

Rheumatoid Arthritis

•Antibody against Fc of IgG

•Female, 40-50

•Pannus

•Synovitis and morning stiffness

•Joint deformity