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The core‐shell nanoparticles are composed of two or more materials which can be synthesized with different combinations of inorganic and organic materials. Their functionality and stability can be increased by coating. Superparamagnetic iron oxide nanoparticles (SPIONs) are one of the most common core‐shell nanoparticles that are used in medical imaging and therapy (Damascelli et al. 2001; Gholami and Engel 2018). Their biocompatible polymer coating and core surface modification enable their use in nanomedicine and nuclear medicine applications. SPIONs exhibit magnetization only in an applied magnetic field and are able to load drugs and medical radioisotopes (due to their highly active surface) (Gholami and Engel 2018). There are key advantages of SPION drug delivery including longer circulation half‐lives, improved pharmacokinetics, capability of carrying a large amount of drugs, reduction in side effects, and targeting the drug to a specific location in the body (Laroui et al. 2011).