Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 47

 Epigenetic alterations play a significant role in T‐cell lymphomas, largely through DNA methylation and histone modification that result in changes in gene expression.

 Mutations resulting in gain and loss of function of epigenetic genes are seen in varying frequency and different combinations across the different subsets of T‐cell lymphomas.

 These genetic derangements are attractive therapeutic targets. The efficacy of single agents that target the epigenome is well established and rational combinations offer a paradigm changing approach to management.