Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 50

PTCL oncogenesis is a complex process thought to comprise two distinct components: one involving the dysregulation of T‐cell receptor signaling pathways intrinsic to malignant T cells, the other involving the interplay between the malignant cell and the non‐neoplastic tumor microenvironment. In addition, in select PTCL subtypes, the neoplastic transformation can be driven by viruses and chronic inflammation. In addition to the extensive epigenetic dysregulation discussed above, it is now becoming clear that a host of other molecular derangements can contribute to dysregulation of the PTCL epigenome, including but not necessarily limited to chromosomal translocations, insertions, deletions, point mutations, can result in unique fusion proteins, constitutive activation of driver pathways and gene loss [59, 60].

Figure 3.2 A simplified schematic of the action of histone deacetylase inhibitor.