Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 51

Epigenetic mutations are less frequent in PTCL‐NOS than in AITL (see section 3.3.2). There are reports of mutations in epigenetic regulators including KDM6A, MLL2, TET2, and DNMT3 which control genes involved in various signaling pathways including ZAP70, CHD8, APC, and TRAF3. Most importantly, a subgroup of PTCL is now defined as PTCL with T follicular helper (Tfh) cell phenotype (see below) and is now a separate category to PTCL‐NOS as defined by the World Health Organization classification.