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 The best way to predict disease is to first create a risk profile.

 The main risk factors for disease are often attributable to genetics, environmental, and lifestyle characteristics, and existing conditions that can lead to co‐morbidities.

 Early detection of disease depends on both genotypic and phenotypic testing.

 It is important to realize that it is not possible, or even advisable, to use predictive tests to try to eliminate all deleterious alleles from a breeding line.

 Bias exists in most forms of research citing predisposition to disease; the information still has validity, but needs to be appreciated in context.