Читать книгу Intracranial Gliomas Part III - Innovative Treatment Modalities - Группа авторов - Страница 31

In 1971, Sutton [1] for the first time proposed the use of hyperthermia for treatment of intracranial tumors, and Bown [2] later suggested that energy generated with the neodymium:yttrium aluminum garnet (Nd:YAG) laser may be directed to targets in conjunction with fiber optic applicators that fit easily through small introduction needles, offering thus an excellent means of minimally invasive treatment. Contemporary laser-induced interstitial thermotherapy (LITT) is a procedure applied for destroying tissue through the local generation of heat. It is one of a variety of thermal therapies or thermal surgeries used for management of brain neoplasms, which also include cryodestruction [3] and hyperthermia ablation attained with radiofrequency (RF) current [4], microwaves [5] and high-intensity focused ultrasound (HIFU) [6]. Compatibility with image guidance makes these techniques attractive for precise focal tissue destruction. This chapter highlights basic principles of LITT and its neurobiological effects, describes contemporary surgical technique with the use of modern technological devices, and provides a systematic review of the clinical application of this modality in patients with intracranial gliomas.