Читать книгу Intracranial Gliomas Part III - Innovative Treatment Modalities - Группа авторов - Страница 40

LITT has been developed gradually during recent decades and its safety and efficacy have been tested in cases of various intracranial neoplasms, as well as non-neoplastic pathology (e.g., mesial temporal sclerosis). Providing anatomically and physiologically personalized minimally invasive treatment, LITT may be considered as a potentially beneficial local therapeutic option in cases of gliomas not suitable for resection or refractory to standard management. Development of iMRI scanners (open and closed) and advanced software currently allows real-time (or nearly real-time) imaging of the temperature-induced tissue changes (MR thermometry) and enables the surgeon to perform precise treatment planning and visual monitoring of the procedure; it also provides constant feedback about the 3D spatial distribution of the tissue thermal damage. Low risk of treatment-related morbidity has the added benefit of leading to a substantially reduced cost of hospitalization. While the overall number of patients with glioma, particularly those newly diagnosed, treated with LITT is still low, it continues to increase due to demonstrated treatment effectiveness and its evident clinical advantages, which should be evaluated further in randomized clinical trials.