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The next highlight in the career of Claude Bernard was his discovery of glycogen and its role in metabolism. On September 24, 1855, he reported to the medical academy in Paris: “Once having washed the liver with water 24 h later you can discover glucose in the vena hepatica. There must have been a production of new glucose. Where does it come from?” Finally, in February 1857, he isolated glycogen and wrote in his notebook: “I baptize this substance glycogen” (Fig. 3). The summary of the work was published in 1857 as “Nouvelles recherches expérimentales sur les phénomènes glycogéniques du foie” [3].