Читать книгу Anterior Skull Base Tumors - Группа авторов - Страница 37

A diagnostic challenge is mainly encountered with the solid form of adenoid cystic carcinoma, which needs to be differentiated from basaloid squamous carcinoma, malignant melanoma, and neuroendocrine carcinoma. p63 and p40 positivity may direct the diagnosis towards basaloid squamous carcinoma, though this finding can also be present in the myoepithelial component of adenoid cystic carcinomas which has a dual cell population in the tubular and cribriform pattern. Solid adenoid cystic carcinoma is typically derived from the duct-like component and is therefore negative for p63 expression or may show rare positive peripheral cells. Melanoma is positive for melan-A, HMB45, and tyrosinase staining.