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Adenocarcinoma of the Pancreas. For adenocarcinomas of the pancreas, if resectable, surgery is the initial option (Whipple’s procedure for tumors in the head or uncinate process and distal pancreatectomy and splenectomy for tumors in the body and tail) with adjuvant chemotherapy. In cases of non-resectable disease or metastatic disease patients are treated with chemotherapy.

Acinar Cell Carcinoma. Treatment of ACC is similar to that of PDAC.

High-Grade Neuroendocrine Carcinoma (Small Cell and Large Cell Type). These tumors are treated with chemotherapy regimens that are similar to small cell carcinomas of the lung [44].

Pancreatoblastoma. Surgical resection with adjuvant or neoadjuvant chemotherapy is the preferred treatment for pancreatoblastomas.

Lymphoma. Lymphomas are medically managed depending upon the specific type, including histologic morphology, flow cytometry, and cytogenetic findings.

Metastases. Diagnosis of metastasis generally indicates a widespread malignancy that is managed according to its specific subtype.

For further details, strategies provided by surgical and gastrointestinal specialty organizations, including the British Society of Gastroenterology, the Pancreatic Society of Great Britain, the Royal College of Pathology, the Japan Pancreas Society, the International Association of Pancreatology [45, 46], and the National Comprehensive Cancer Network (NCCN) [47], can be referred to.