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The recorded use of AHAs, BHAs, and PHAs dates back in its earliest form to ancient Egypt, when sour milk was utilized to smooth the skin with the active agent of lactic acid [6]. In the 1800s, chemical elements including phenol, lime, and croton oil were used to lighten freckles and treat melasma under the aegis of stratum corneum exfoliation; only mere decades later, sulfur and resorcinol were used for skin rejuvenation. In the middle of the twentieth century, Jessner’s peel solution was created and pioneered by the German dermatologist Max Jessner when salicylic acid, resorcinol, and lactic acid were combined [7].

Later, the well-documented acid known as trichloroacetic acid (TCA) came into the picture. To this day, it is one of the most widely used chemical peeling agents to treat wrinkles, acne, pigmentation, texture, and actinic damage by reaching a medium-depth of the skin and stimulating fibroblast type I collagen production [6]. Fast-forward to modern-day dermatology, we are now armed with the knowledge of the numerous peeling agents’ depth of reach as well as the extensive and ever-evolving database of lasers which allow for skin resurfacing results that are more accurate than ever.