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Antibacterial activity of amniotic fluid

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Although bacteria may occasionally be isolated from the AF of asymptomatic patients,385, 386 the rarity of infection following millions of amniocenteses during the second and third trimesters of pregnancy clearly suggests a protective mechanism against bacterial infection in AF. The implication was that AF has specific antibacterial activity. Some investigators have concluded that AF has some antibacterial activity,386, 387 whereas others maintain that it has none or that it actually provides a good culture medium.388, 389 A substance bactericidal for Bacillus subtilis was found in about 17 percent of AF samples in one study.390

Genetic Disorders and the Fetus

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