Читать книгу Genetic Disorders and the Fetus - Группа авторов - Страница 94

Circulating cell‐free DNA in AF is potentially useful for prenatal diagnosis, although its presence in maternal serum has already been widely adopted⁶⁴ (see Chapter 7). A whole‐genome microarray analysis of RNA isolated from AF obtained at term and second trimester identified nearly 3,000 significant differences in gene transcripts.⁶⁵ Many of the differences reflected enrichment of transcripts associated with fetal maturity, and may have value in studies of normal and abnormal fetal development.