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Clinical Dilemmas in Diabetes
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Страница 1
Table of Contents
List of Tables
List of Illustrations
Guide
Pages
Страница 7
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Страница 9
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Страница 11
1 “Is Prediabetes a Risk Factor or Is It a Disease?”
LEARNING POINTS
What is prediabetes?
Rationale for the diagnostic criteria for diabetes mellitus and prediabetes
Epidemiology of prediabetes
Pathogenesis of impaired fasting glucose and impaired glucose tolerance
Screening recommendations for prediabetes
Reproducibility, sensitivity, and specificity of glycemic measurements and the role of oral glucose tolerance testing in clinical practice
Risk of progression from prediabetes to diabetes mellitus
Microvascular complications associated with prediabetes Retinopathy
Nephropathy
Neuropathy
Macrovascular complications and mortality associated with prediabetes
Management of prediabetes
Diabetes prevention program
Da Qing study
Pharmacologic therapy for the prevention or delay of diabetes mellitus
Bariatric surgery for the prevention or delay of diabetes mellitus
Exercise and diet for the prevention or delay of diabetes mellitus
American diabetes association 2020 guideline recommendations for the management of prediabetes
Conclusion
References
2 Early Diagnosis of Type 1 Diabetes – Useful or a Pyrrhic Victory?
LEARNING POINTS
Introduction
Pathogenesis of T1D: An Update in View of Defining Preventive Tools
What Are the Environmental Factors Triggering Type 1 Diabetes?
The Role of Cow's Milk
The Role of Vitamin D Deficiency
Prediction of T1D as the Basis for Disease Prevention
Prevention of T1D: Current Status
Primary Prevention
Secondary Prevention
European Nicotinamide Diabetes Intervention Trial (ENDIT)
DPT‐1 Trials
Type 1 Diabetes Prediction and Prevention Study (DIPP)
Tertiary Prevention
Immune Intervention Therapies at Diagnosis of T1D
Incretin‐based Therapies
Conclusions
Acknowledgments
References
3 Reclassifying or Declassifying Diabetes? Can Clinical Characteristics Guide Classification and Treatment?
LEARNING POINTS
The pathophysiology of hyperglycemia – type 1 vs type 2 diabetes
Genetic and environmental influences on disease presentation
Measuring insulin secretion
Autoantibodies
“Atypical” diabetes, glucose toxicity and the honeymoon period
Cystic fibrosis‐related diabetes
Novel approaches to reclassifying diabetes
Conclusions
Bibliography
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