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Deoxyribozyme logic gate works as YES gate if it is modified by including a single stemloop region which regulates the binding of substrate, as explained in the previous subsection. The substrate cannot bind to deoxyribozyme if the stem-loop is in closed form. As a result, the enzyme is inactivated as no output can be produced. Addition of input single stranded DNA sequence causes the hybridization of it to the loop region and breakage of stem-loop structure. This conformational change activates the enzyme. Now, the substrate binding regions are free to hybridize which causes the cleavage of the substrate. Now, the output DNA signal can be produced. This mechanism is shown in Figure 2.14, where a single input ix activates the YESx logic gate. Table 2.4 represents the truth table for YES gate.

Figure 2.14 Mechanism of YES gate.

Table 2.4 Truth table for YES gate.

Input (ix)	Output (iy)
0	0
1	1