Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 624

Management of MDS comprises supportive care and disease‐modifying agents. Supportive should be given to all patients, while high‐risk patients may be offered active treatments ranging from hypomethylating agents to intensive chemotherapy and haematopoietic stem cell transplantation. Recently, new agents have been proposed for treatments of low‐risk disease.

Treatment choice in older adults should not be based only on chronological age but should also take into consideration haematological variables (IPSS score, genetic risk) as well as variables derived from a CGA (comorbidity burden, self‐sufficiency, frailty status) and life expectancy. Patient preferences should always be taken into account.