Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 636

 Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by dysplasia, ineffective haematopoiesis, and potential risk of transformation into acute leukaemia.

 In MDS, the important predictors for overall prognoses are cytogenetic abnormalities, percentage of myeloblasts in the bone marrow, and number of lineages that exhibit cytopenias.

 Because the defect in MDS occurs in an early haematopoietic precursor, allogeneic transplant represents a potentially curative option.