Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 633

The goal of treatment for patients with high‐risk MDS is to limit disease progression and improve survival rates. In general, feasibility of allo‐HSCT should be considered even in older adults and at least for young‐older adults (65–75 years old) in good clinical condition. CGA can be extremely useful in selecting candidates for transplantation.

For those not suitable for allo‐HSCT, hypomethylating agents are a good alternative. Given the limited impact on the disease course in high‐risk groups and the possible significant effects on quality of life, CGA is highly recommended when planning treatment. Best supportive care still remains the most reasonable option for very frail patients with severe multimorbidity, overt disability, and limited life expectancy.