Читать книгу Veterinary Surgical Oncology - Группа авторов - Страница 107

Mast Cell Tumors (MCTs) are the most common malignant cutaneous tumor in dogs and the second most common cutaneous tumor in cats (Miller et al. 1991; Villamil et al. 2011; Shoop et al. 2015; Graf et al. 2018). Cutaneous MCTs arise from the dermis and subcutaneous tissues. MCTs are round cell tumors that have characteristic cytoplasmic granules that contain bioactive substances, including histamine, heparin, proteases, chemotactic factors, and cytokines. There is a large degree of variation in the histologic appearance and biological behavior of MCTs in dogs.