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A pretreatment biopsy is indicated in the following situations:

 If the type of treatment will be altered by knowledge of tumor type. For example, cutaneous lymphoma (chemotherapy) vs. FSA (surgery)

 If the extent or surgical dose of treatment would be altered by knowledge of tumor grade, for example, grade III soft tissue sarcoma on an extremity (amputation or wide resection plus or minus adjunctive therapy) vs. grade I soft tissue sarcoma on an extremity (marginal resection)

 If tumor location is in an anatomical location with difficult or limited reconstructive options

 When knowledge of tumor type and grade affects the owner’s willingness to pursue treatment based on prognosis (Ehrhart 2005)

Biopsy techniques for skin tumors include needle core, incisional, and excisional biopsies (for technique description see Chapter 1).