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Disposable 14‐ or 16‐gauge needle core biopsy needles provide enough tissue for a pathologist to make a histologic diagnosis and, in most cases, provide a grade of skin tumors. Multiple (3–6) biopsy samples should be obtained to maximize the probability of an accurate diagnosis. Generally, the needle core biopsy can be done as an outpatient procedure with only local anesthesia and/or light sedation required.

Needle core biopsy is reported to accurately predict surgical biopsy with an overall sensitivity of 95.5%, specificity of 96.6%, and a positive predictive value of 95.5% (Aitken and Patnaik 2000). Thus, needle core biopsy performed before surgical excision of cutaneous masses can facilitate surgical planning and reduce the need for multiple surgical procedures.