Читать книгу Biomolecules from Natural Sources - Группа авторов - Страница 54

Insulin was engineered through mutagenesis to create monomeric forms that are fast acting (insulin lispro and insulin aspart). Conversely, another form (insulin glargine) was created by mutagenesis to precipitate upon injection and give a sustained release of insulin. More research was done on insulin. Whittingham et al. 1997 reported a crystal structure of a prolonged-acting insulin with albumin-binding properties [116].