Читать книгу Biomolecules from Natural Sources - Группа авторов - Страница 55

A catalytic antibody is a variant of an antibody. Antibodies are proteins that normally bind to a specific molecule but do not alter the bound molecule in any way. A catalytic antibody is one which was changed by mutations to have a novel sequence that folds into a structure that catalyzes a specific reaction (such as amide bond formation, ester hydrolysis, and decarboxylation). Catalytic antibodies function like enzymes, and are created to catalyze reactions for which there are no naturally occurring enzymes. Fifty or more different reactions have been catalyzed by the action of catalytic antibodies that were obtained individually by methods of protein engineering [117].