Читать книгу Transfusion Medicine - Jeffrey McCullough - Страница 110

Adverse reactions in apheresis donors (Table 4.5) are similar in character to those encountered in whole blood donation. Although double red cell collections by cytapheresis are now common, most cytapheresis procedures carried out in normal donors are plateletpheresis. Because the required interval between double red cell donation is proportionally increased, the long‐term potential for anemia/ferritin deficiency is probably similar to whole blood donation, although acute changes with each donation are greater. Normal donors undergoing plateletpheresis may report an adverse reaction following up to 50% of procedures when asked; however, such reactions cause the procedure to be discontinued only 0.1–1.0% of the time [81]. These reactions are almost entirely due to citrate toxicity and can be alleviated by slowing the rate of blood return and thus the rate of citrate infusion.

Some potential complications of apheresis apply to all types of procedures because they have to do with the instrument or activities that are common to all types of procedures, while others are unique to certain apheresis procedures [81–83].