Читать книгу Transfusion Medicine - Jeffrey McCullough - Страница 122

Because of the low level of circulating PBSCs in normal donors, donors receive the hematopoietic growth factor G‐CSF to mobilize PBSCs and increase the yield. G‐CSF is also often used, sometimes in combination with glucocorticoids, to increase yields for granulocyte collections. G‐CSF, itself, is associated with a high frequency of side effects and is responsible for most of the complications of the donation of mononuclear cells as a source of PBSCs [107].