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Platelet depletion or damage

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Plateletpheresis does not damage the donor’s remaining platelets, and the donor’s platelet function is normal after donation [93]. Removal of platelets equivalent to several units of the donor’s blood does not result in thrombocytopenia. In a rather dramatic example, a female donor underwent 101 donations during a 33‐month period, with donation frequencies ranging from once to three times weekly [94]. Her platelet count remained in the range of 135,000–430,000 during this time. In donors who undergo repeated plateletpheresis, the platelet count decreases somewhat more, but then stabilizes [78, 95]. Thus, it appears that platelets can be donated safely approximately every 2–4 days if needed.

Transfusion Medicine

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