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The complications related to leukapheresis itself are not different from those in plateletpheresis, but donors receive HES, corticosteroids, and possibly G‐CSF that can cause additional problems. Although there are only a few studies of side effects in frequent granulocyte donors [106], experience with stem cell donors has also provided information about side effects [107]. Short‐term effects of HES include rashes and fluid shifts, while the effects of corticosteroids and G‐CSF are also well known and are discussed in Chapter 6. Although there have been concerns about long‐term effects, such as cataracts [108, 109] or malignancy [110], in repeat donors, these have not been confirmed in studies.