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Kenneth N Kreuzer
Replicating And Repairing The Genome: From Basic Mechanisms To Modern Genetic Technologies
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Dedication
Preface
Acknowledgments
Contents
About the Author
Chapter 1 The challenges of maintaining and duplicating the genome 1.1Introduction
1.2The double-helical structure of DNA and the logic of replication and repair
1.3The key functions needed for the process of DNA replication
1.4Repairing and tolerating damage to the DNA molecule
1.5Summary of key points
Further Reading
How did they test that?
The base composition of DNA and Chargaff’s rule
Chapter 2 The simple DNA replication system of a bacterial virus 2.1Why the interest in a bacterial virus?
2.2The four proteins involved in T7 DNA replication
2.3Activities of T7 DNA polymerase in the replisome
2.4Mechanisms of unwinding by the T7 helicase
2.5The replisome machine functions with a looped lagging-strand template
2.6Structural model for the T7 replisome
2.7T7 ssDNA-binding protein helps to organize the replisome
2.8Finalizing the lagging-strand product
2.9Back to the beginning — How does T7 DNA replication initiate?
2.10Summary of key points
Further Reading
How did they test that?
Are leading- and lagging-strand synthesis coupled?
Chapter 3 The highly efficient replication system of bacteria
3.1The
E. coli
replisome from 30,000 feet
3.2The replicative DNA polymerase holoenzyme
3.3Dynamics of clamp loading in bacterial replication
3.4Coordinated action of helicase, primase, and DNA polymerase holoenzyme
3.5The
E. coli
ssDNA-binding protein
3.6Housekeeping after the replisome passes — Repairing Okazaki fragments, reducing replicative errors, and recycling clamps from the DNA
3.7Replication restart and other rescue pathways
3.8Summary of key points
Further Reading
How did they test that?
Does the sliding clamp encircle DNA?
Chapter 4 Eukaryotic DNA replication
4.1Special challenges of replicating multiple linear chromosomes
4.2How do eukaryotic replication proteins compare to their prokaryotic counterparts?
4.3MCM complex — the replicative helicase in eukaryotes
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