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Contents

Оглавление

Preface

Acknowledgments

About the Author

Chapter 1The challenges of maintaining and duplicating the genome

Chapter 2The simple DNA replication system of a bacterial virus

Chapter 3The highly efficient replication system of bacteria

Chapter 4Eukaryotic DNA replication

Chapter 5Replication dynamics — initiating, regulating and terminating cellular DNA replication

Chapter 6Postreplication repair of mismatches and ribonucleotides

Chapter 7DNA topology and the enzymes that alter it

Chapter 8DNA damage — a persistent threat to the genome

Chapter 9Direct reversal of DNA damage

Chapter 10Excision repair — taking advantage of the complementary strand

Chapter 11Repair of double-strand breaks

Chapter 12DNA damage tolerance and translesion DNA polymerases

Chapter 13DNA damage response pathways

Chapter 14DNA replication and repair in human disease

Chapter 15Enzymes of DNA replication and repair fuel modern genomic technologies

Appendix

Index

Replicating And Repairing The Genome: From Basic Mechanisms To Modern Genetic Technologies

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