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Chemical Constituents and Mechanism of Action

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Two forms of aloe are dried leaf juice and aloe gel.75 Latex from the pericyclic cells obtained beneath the skin of leaves may be evaporated to form a sticky substance known as “drug aloes” or “aloe.” This aloe juice contains cathartics including anthraquinone, barbaloin, a glucoside of aloe-emodin, and other substances. Aloe gel, however, is the ingredient relevant to diabetes. It comes from the inner portion of leaves and does not contain cathartics, but it does contain the polysaccharide glucomannan, which is similar to guar gum.75 Active ingredients include polysaccharides and glycoprotein, but although the definitive mechanism of action is unknown, the high fiber content alone may promote glucose uptake.109

Complementary and Alternative Medicine (CAM) Supplement Use in People with Diabetes: A Clinician's Guide

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