Читать книгу Complementary and Alternative Medicine (CAM) Supplement Use in People with Diabetes: A Clinician's Guide - Laura Shane-McWhorter - Страница 50

Active ingredients include corsolic acid and tannins, including the ellagitannin lagerstroemin. Besides ellagitannins and lagerstroemin, flosin B and reginin A are thought to be glucose-transport enhancers.¹¹⁴ The ellagitannins are plant polyphenols, which reportedly bind to several polypeptides such as the regulatory subunit of protein kinase A. The active ingredients are thought to stimulate glucose uptake and have insulin-like activity. The latter activity is thought to be secondary to activation of insulin receptor tyrosine kinase or the inhibition of tyrosine phosphatase. Activation of tyrosine kinase causes tyrosine phosphorylation of several proteins, which then induce the functional change of signaling molecules such as phosphatidylinositol 3-kinase.¹¹⁵ Animal research has shown that banaba may inhibit alpha-amylase and alpha-glucosidases and thus potentially lower elevated postprandial glucose.⁷⁵