Читать книгу Complementary and Alternative Medicine (CAM) Supplement Use in People with Diabetes: A Clinician's Guide - Laura Shane-McWhorter - Страница 47

In one very small uncontrolled study, five patients with type 2 diabetes were administered one-half teaspoonful dried aloe sap twice daily for 4–14 weeks.¹¹² Information regarding blinding was not provided. Fasting glucose decreased from a mean 273 mg/dl (15.2 mmol/l) to 151 mg/dl (8.4 mmol/l; P < 0.001). Mean A1C also decreased from 10.6% to 8.2% (P value not reported).

A 6-week single-blind, placebo-controlled study was done in 40 patients with newly diagnosed type 2 diabetes.¹⁰⁹ Aloe vera juice was pre pared from aloe gel. The patients received 1 tablespoonful aloe gel twice daily or placebo for 6 weeks. Fasting blood measurements were taken weekly, and triglyceride and cholesterol levels were measured every 2 weeks. Fasting glucose declined significantly from 250 mg/dl (13.9 mmol/l) at baseline to 142 mg/dl (7.9 mmol/l) after 6 weeks in the aloe group (P = 0.01). Total cholesterol remained unchanged, but triglycerides declined from 220 mg/dl (2.5 mmol/l) to 123 mg/dl (1.4 mmol/l; P = 0.01).

Another 6-week single blind controlled trial in 40 patients with type 2 diabetes evaluated the addition of 1 tablespoonful aloe gel or placebo twice daily to the sulfonylurea glibenclamide, 5 mg twice daily.¹¹⁰ Fasting glucose declined significantly from 288 mg/dl (16.0 mmol/l) to 148 mg/dl (8.2 mmol/l; P = 0.01 vs. control) in the aloe vera group. Total cholesterol remained the same: 230 mg/dl (5.95 mmol/l) at baseline and 226 mg/dl (5.80 mmol/l) after 6 weeks. However, triglycerides declined significantly from 265 mg/dl (3.0 mmol/l) to 128 mg/dl (1.5 mmol/l; P = 0.01 vs. control).