Читать книгу Canine and Feline Epilepsy - Luisa De Risio - Страница 149

Onset and type or clinical signs are dose-dependent. Dogs ingesting 2.5 to 5 mg/kg of bromethalin develop clinical signs in 1 to 4 days (Murphy, 2002), whereas dogs ingesting more than 5 mg/kg of bromethalin may develop clinical signs within 2–24 h after ingestion. Low doses (e.g. 2.5 mg/kg in dogs) result in pelvic limb ataxia and/or paresis/paralysis with extensor rigidity and obtunded mental status. High doses (e.g. 5 to 6.5 mg/kg in dogs) produce hyperexcitability, tremors, focal motor and generalized seizures, hyperthermia, obtunded mental status, which can progress to stupor, coma, decerebrate posture and death secondary to respiratory arrest (Dorman et al., 1990a, b). Cats ingesting 0.54 mg/kg develop signs (including ataxia, focal motor seizures, vocalization, obtunded mental status and stupor) 2 to 7 days after exposure (Dorman et al., 1990c). Most recently clinical signs and death have been reported following exposure to bromethalin doses as low as 0.46 mg/kg in dogs and 0.24 mg/kg in cats (DeClementi and Sobczak, 2012).