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There is no antidote to bromethalin. Treatment involves decontamination and prevention of further toxin adsorption (induction of emesis or gastric lavage followed by repeated administration of activated charcoal and administration of a cathartic with the initial dose of activated charcoal) (Table 4.1), AEMs (see Table 4.1 and Chapters 12 and 24) in seizuring animals, methocarbamol or diazepam in animals with excessive tremors (Table 4.1), and supportive care. The repeated and prolonged administration of activated charcoal (1–5 g/kg every 6–8 h for up to 2–4 days in animals ingesting high dosage of bromethalin) is indicated due to the enterohepatic recirculation of bromethalin. Cerebral oedema can be treated with mannitol. Serum sodium levels should be closely monitored due to the potential for hypernatraemia of repeated administration of activated charcoal as well as mannitol.