Читать книгу Canine and Feline Epilepsy - Luisa De Risio - Страница 17
Nonsynaptic mechanisms Alterations in ionic microenvironment
ОглавлениеRepetitive ictal and interictal activity causes increases in extracellular K+ leading to increased neuronal excitability (Moody et al., 1974). Some neurons are very sensitive to changes in membrane K+ currents, e.g. pyramidal cells in the CA1 region of the hippo-campus (Rutecki et al., 1985).