Читать книгу Canine and Feline Epilepsy - Luisa De Risio - Страница 23

In rodent models, altering glutamate receptor or glutamate transporter expression by knockout or knockdown procedures can induce or suppress epileptic seizures (Chapman et al., 1996; Kabova et al., 1999; Chapman, 2000). Regardless of the primary cause, synaptically released glutamate acting on ionotropic and metabotropic receptors appears to play a major role in the initiation and spread of seizure activity (Meldrum, 1994; Chapman et al., 1996; Chapman, 2000). Glutamatergic synapses play a critical role in all epileptic phenomena. Activation of both ionotropic and metabotropic postsynaptic glutamate receptors is proconvulsant. Antagonists of N-methyl-D-aspartate (NMDA) receptors are powerful anticonvulsants in many animal models of epilepsy. Several genetic alterations have been shown to be epileptogenic in animal models.