Читать книгу Canine and Feline Epilepsy - Luisa De Risio - Страница 27

On account of these receptors’ responsibility for regulating glutamatergic and GABA-ergic neurotransmission, it is not surprising that mGluRs strongly influence the induction, propagation and termination of epileptic activity in the central nervous system (CNS) (Doherty and Dingledine, 2002). Pharmacological studies with mGluR group specific agonists and antagonists provide a relatively clear picture for Group I, with agonists being convulsant and antagonists being anticonvulsant (Meldrum et al., 1999; Doherty and Dingledine, 2002; Sayin and Rutecki, 2003). The picture is more complicated for the Group II and III receptors but anticonvulsant effects have been described for agonists of both these groups (Meldrum et al., 1999).