Читать книгу Canine and Feline Epilepsy - Luisa De Risio - Страница 32

In experimental studies, opioids and opioid peptides had both convulsant and anticonvulsant properties (Engelborghs et al., 2000). Kappa agonists suppress electrical discharges in an animal model of absence epilepsy (Przewlocka et al., 1995). Peptides with a μ-agonist action induce hippocampal or limbic seizures when administered intraventricularly possibly due to inhibition of inhibiting interneurons. In patients with complex partial seizures, PET studies pointed out that μ-receptor density is increased in the temporal cortex (Mayberg et al., 1991).