Читать книгу Canine and Feline Epilepsy - Luisa De Risio - Страница 25

AMPA receptor antagonists, either competitive or non-competitive, are anticonvulsant in rodent models (Rogawski and Donevan, 1999). Thus, altered function of AMPA receptors could contribute to proconvulsant or anticonvulsant effects (Meldrum et al., 1999). Evidence has accumulated that Ca2+-permeable AMPA receptors may play a role in epileptogenesis and the brain damage occurring during the prolonged seizures (Rogawski and Donevan, 1999). Because Ca2+-permeable AMPA receptors are predominantly expressed in GABA-ergic inter-neurons, it is hypothesized that some forms of epilepsy might be caused by reduced GABA inhibition resulting from Ca2+-permeable AMPA receptor-mediated excitotoxic death of interneurons (Rogawski and Donevan, 1999).