Читать книгу Canine and Feline Epilepsy - Luisa De Risio - Страница 18

Activation of the Na+–K+ pump is important for regulation of neuronal excitability during excessive neuronal discharges. Substances like ouabain that block the Na+–K+ pump can induce epileptogenesis in animal models. Hypoxia or ischaemia can result in Na+–K+ pump failure thus promoting interictal–ictal transition. A Cl−–K+ co-transport mechanism controls the intracellular Cl− concentration and the Cl− gradient across the cell membrane, which regulates effectiveness of GABA-activated inhibitory Cl− currents. Interference with this process could cause a progressive decrease in the effectiveness of GABA-ergic inhibition leading to increased excitability (Engelborghs et al., 2000).