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ACKNOWLEDGMENTS

My sincere thanks are due to Prof. Amin Rostami‐Hodjegan who reviewed chapters of the book relating to applications of PBPK modeling, despite other demands on his time. Being at the forefront of research in the field of PBPK modeling, his suggestions were very valuable in structuring the content and updating the chapters with the latest developments in the area. I am grateful to Adam Darwich, Nicola Melillo, Dan Liu, and Alexander Cooper whose help with reviewing my chapters is greatly appreciated. I would like to thank my colleagues at Merck Healthcare KGaA, Joao NS Pereira, Ulrike Graadhand, Andreas D Becker, and Akash Khandelwal who also helped review some of the chapters, and Rainer Strotmann for letting me use some figures he created. My deep appreciation goes to Christina Peters for finding time in the midst of her busy career to create some excellent figures for this edition. I would like to acknowledge the enthusiastic support I received from Vignesh Murugesan for gathering some data for the book. I am extremely grateful to Jan Schlender, Annika Schneider, and Michael Krug, who over the last two years, devoted their time to creating the case studies in PK‐Sim as well as HELP manuals. This work would not have been possible without the consistent support extended by my friends and family.