Читать книгу Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations - Sheila Annie Peters - Страница 15

1  1.1 Introduction

2  1.2 Pharmacokinetic Principles 1.2.1 Routes of Drug Administration 1.2.2 Intravenous Bolus 1.2.3 Plasma Protein Binding and Blood–Plasma Ratio 1.2.4 Hepatic, Renal, and Biliary Clearances 1.2.5 Extravascular (Subcutaneous, Intramuscular, and Per Oral) Absorption 1.2.6 Absorption from Solid Dosage Forms 1.2.7 Role of Transporters in ADME 1.2.8 Linear and Non‐Linear Pharmacokinetics 1.2.9 Intravenous Infusion, Repeated Dosing, Steady State Kinetics, and Accumulation 1.2.10 Active Metabolite and Prodrug Kinetics

3  1.3 Pharmacokinetic Variability

4  1.4 Pharmacokinetics Optimization in Drug Discovery

5  1.5 Pharmacodynamic Principles 1.5.1 Pharmacological Targets and Drug Action 1.5.2 Functional Adaptation Processes 1.5.3 Biomarkers, Surrogate Endpoints, and Clinical Endpoints Keywords References