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1.2 PHARMACOKINETIC PRINCIPLES 1.2.1 Routes of Drug Administration

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Common routes of drug administration include per oral (PO), intramuscular (IM), subcutaneous (SC) intravenous (IV) bolus and infusion, and intrathecal (around the spinal cord). Other less common routes include buccal, sublingual, rectal, transdermal, inhalational, and topical. The oral route is the most preferred route, but it is not suitable for drugs that are not stable in the gut, like for example peptide and protein drugs.

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations

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