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2 A REVIEW OF DRUG–DRUG INTERACTIONS CONTENTS

Оглавление

1  2.1 Introduction

2  2.2 Drug Interactions Mediated by Enzymes and Transporters at Various Sites

3  2.3 Factors Affecting DDI

4  2.4 In Vitro Methods to Evaluate Drug–Drug Interactions 2.4.1 Candidate Drug as a Potential Perpetrator 2.4.2 Candidate Drug as a Potential Victim of Inhibition

5  2.5 Sources of Uncertainty

6  2.6 Therapeutic Protein–Drug Interaction Keywords References

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations

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