Читать книгу Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations - Sheila Annie Peters - Страница 58

Cytokines:Cytokines are a large group of proteins, peptides, or glycoproteins secreted by specific cells of immune system. They act as signaling molecules and mediate and regulate immunity, inflammation, and hematopoiesis.Mechanism‐based inhibition:MBI is a potential mechanism for TDI, where a more inhibitory metabolite relative to parent, causes the inactivation of a CYP by a protein or heme adduct formation.Reaction phenotyping:is the estimation of the relative contributions of specific enzymes to the metabolism of a test compoundTime‐dependent inhibition (TDI):TDI is a collective term that refers to the increase in the extent of inhibition of the substrate, when the inhibitor is incubated with the enzyme prior to the addition of the substrate in vitro or during the dosing period in vivo.