Читать книгу Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations - Sheila Annie Peters - Страница 53
2.4 IN VITRO METHODS TO EVALUATE DRUG–DRUG INTERACTIONS
ОглавлениеA candidate drug must be evaluated for its potential to be a perpetrator or victim of DDI with likely coadministered drugs. In vitro methods that aid this assessment focus on reversible/irreversible inhibition or induction mediated by an enzyme or a transporter.